Patrick Souillot became a student of Leonard Bernstein in 1986 and soon after started working as his assistant. He accompanied him in his 70th birthday celebration tour with the Schleswig Holstein Musik Festival Orchestra. He then accompanied the maestro to Vienna, Amsterdam, Munich and many other cities around the world.

Laureate of many international competitions, Souillot was awarded in 1988 the 1st Prize of the Davidoff Competition in Hamburg, Germany. Since then his guest conducting appearances have taken him all over the world to lead prestigious orchestras such as the London Symphony Orchestra, Krakow Academy Orchestra, Montpellier National Orchestra, the Latvian National Orchestra, the Macedonia National Orchestra, and others.

In parallel to his international career, Souillot has been serving since 1989 as the conductor of the University Symphonic Orchestra in Grenoble, France. In September 2001, Sir Colin Davis invited him to lead the London Symphony Orchestra for the "Conducting Discovery Day."

Souillot has made many recordings with prestigious orchestras and worked with soloists such as Marie-Claire Alain, Patrice Fontanarosa and François-René Duchable. He is interested in all sorts of music and also records music for films, ballets and theaters.

Souillot directed the Sofia Symphony Orchestra for the recording of Ocean wonderland 3D and Sharks 3D.